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- Take Tyrokin 400 with food and a full glass of water to minimize nausea.
- Take this medicine as prescribed by your doctor, with food and a full glass of water. Swallow the tablet whole; do not chew, crush, or break it.
- Avoid driving or tasks requiring focus if you feel dizzy or have blurred vision.
- Notify your doctor if you experience rapid weight gain, as this may indicate fluid retention or swelling.
- Do not alter the dose or stop treatment without consulting your doctor.
- Inform your doctor about all medications, including over-the-counter drugs and supplements, before starting Tyrokin 400.
- Expect regular blood tests to monitor your liver and blood cell levels during treatment.
- If you forget to take a dose, skip it and continue with your usual schedule. Do not double the next dose to compensate for the missed one.
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✅ Description:
Safety Advices
Alcohol
UNSAFE
It is unclear whether it is safe to consume alcohol while taking Tyrokin 400. Please consult your doctor for advice.
Pregnancy
UNSAFE
Tyrokin 400 is considered unsafe during pregnancy due to clear evidence of risk to the unborn baby. However, in life-threatening situations, your doctor may prescribe it if the potential benefits outweigh the risks. Consult your doctor for guidance.
Breastfeeding
UNSAFE
Tyrokin 400 is likely unsafe for use during breastfeeding. Limited studies suggest that the drug can pass into breast milk and may harm the infant. Breastfeeding should be avoided while using this medication and for at least one month after stopping treatment.
Driving
UNSAFE
Tyrokin 400 may cause side effects like dizziness or blurred vision, which can impair your ability to drive. Use caution when operating vehicles or machinery.
Kidney
CONSULT YOUR DOCTOR
- Tyrokin 400 should be used cautiously in patients with kidney disease. Dose adjustments may be necessary. Consult your doctor for appropriate recommendations.
Liver
CONSULT YOUR DOCTOR
- Patients with severe liver disease should use Tyrokin 400 with caution. A dosage adjustment might be required. Please consult your doctor.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
- Chronic myeloid leukemia (CML)
- Acute lymphocytic leukemia (ALL)
- Gastrointestinal stromal tumors (GISTs)
✔️ How does
Tyrokin 400 works by inhibiting the activity of a specific protein enzyme, bcr-abl tyrosine kinase, which promotes the growth and spread of cancer cells. By targeting this enzyme, the medication prevents the proliferation of cancer cells and induces their planned death (apoptosis).
✔️ Side Effects:
- Rash
- Vomiting
- Abdominal pain
- Diarrhea
- Fatigue
- Water retention and swelling (report rapid weight gain to your doctor)
✔️ Acute Lymphoblastic Leukemia (ALL)
- Relapsed or refractory Philadelphia chromosome-positive (Ph+) ALL.
- Dose: 600 mg orally once daily (PO qDay).
✔️ Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
- Indication: MDS/MPD associated with platelet-derived growth factor receptor (PDGFR) gene rearrangements (confirmed via FDA-approved test).
- Dose: 400 mg PO qDay.
✔️ Hypereosinophilic Syndrome/Eosinophilic Leukemia (HES/CEL)
- Indication:
- With FIP1L1-PDGFR-alpha fusion kinase (via mutational analysis or CHIC2 allele deletion):
- Starting Dose: 100 mg PO qDay.
- Adjustments: Increase to 400 mg PO qDay in the absence of adverse effects if the response is insufficient.
- Fusion kinase negative or unknown: 400 mg PO qDay.
- With FIP1L1-PDGFR-alpha fusion kinase (via mutational analysis or CHIC2 allele deletion):
✔️ Chronic Myeloid Leukemia (CML)
Chronic Phase (Newly Diagnosed)
- Adults and Pediatrics: 400 mg PO qDay.
Chronic Phase (After Failure of Interferon-Alpha Therapy)
- Dose Increase: Up to 600 mg/day if there is disease progression, failure to achieve a hematologic response after 3 months, cytogenetic response after 6-12 months, or loss of response.
Accelerated Phase or Blast Crisis
- Dose: 600 mg PO qDay.
- Increase: Up to 400 mg PO every 12 hours (q12hr) under the same circumstances as above.
✔️ Dermatofibrosarcoma Protuberans (DFSP)
- Indication: Unresectable, recurrent, or metastatic DFSP.
- Dose: 400 mg PO q12hr.
✔️ Aggressive Systemic Mastocytosis (ASM)
- Indication: ASM without D816V c-Kit mutation or with unknown c-Kit mutation status.
- Without D816V mutation: 100 mg PO qDay.
- Unknown mutation status: 400 mg PO qDay.
- ASM with eosinophilia related to FIP1L1-PDGFR-alpha fusion kinase:
- Starting Dose: 100 mg PO qDay.
- Adjustments: Increase to 400 mg PO qDay if needed.
✔️ Gastrointestinal Stromal Tumors (GISTs)
Unresectable/Metastatic Malignant GIST
- Dose: 400 mg PO qDay.
- Adjustments: Increase to 400 mg twice daily (BID) in cases of disease progression without severe side effects.
Adjuvant Therapy (Post-GIST Resection)
- Dose: 400 mg PO qDay for 3 years.
✔️ Hepatic Impairment
- Severe impairment: Reduce dose by 25%.
✔️ Pediatric Dosage Guidelines: Chronic Myeloid Leukemia (CML)
- Indication: Newly diagnosed pediatric patients with Ph+ CML in the chronic phase.
- Dose: 340 mg/m²/day PO, not exceeding 600 mg/day.
- Age: Not established for children under 1 year.
✔️ Pediatric Dosage Guidelines: Acute Lymphoblastic Leukemia (ALL)
- Indication: Newly diagnosed pediatric patients with Ph+ ALL.
- Dose: 340 mg/m²/day PO, not exceeding 600 mg/day.
- Age: Not established for children under 1 year.
✔️ Drug Interactions
CYP3A4 Inhibitors:
- Effect: Increased serum levels of imatinib.
- Examples: Azole antifungals (e.g., ketoconazole), and macrolide antibiotics (e.g., clarithromycin).
CYP3A4 Inducers:
- Effect: Reduced serum levels of imatinib.
- Examples: Carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampicin.
CYP3A4 Substrates:
- Effect: Imatinib may increase serum levels of drugs metabolized by CYP3A4.
- Examples: Ciclosporin, pimozide, triazole-benzodiazepines, dihydropyridine calcium channel blockers, and certain statins.
CYP2C9 Substrates:
- Effect: May elevate serum levels of drugs metabolized by CYP2C9.
- Examples: Warfarin.
CYP2D6 Substrates:
- Effect: Imatinib may increase serum levels of CYP2D6-metabolized drugs.
✔️ Contraindications:
Hypersensitivity. Lactation.
✔️ Precautions & Warnings
- Patients with cardiac disease or an elevated risk for congestive heart failure (CHF) should be closely monitored for severe fluid retention.
- Regularly monitor complete blood count (CBC) to detect cytopenias.
- Monitor liver function tests (LFTs) and renal function periodically.
- Use only if necessary. Potential harm to the fetus exists; advise effective contraception during treatment.
- Imatinib and its active metabolite are excreted into human milk. Advise lactating women not to breastfeed during treatment and for 1 month after the last dose.
✔️ Storage:
Store below 30°C, in a cool and dry place. Keep away from light. Keep out of the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
